ABSTRACT
Objective To evaluate the feasibility and effectiveness of bladder-preserving local resection combined with intra-artery chemotherapy for patients with T1G3 bladder cancer.Methods Thirty five cases with T1G3 bladder cancer were analyzed retrospectively. Patients were all treated by bladder-preserving local resection combined with intra-artery chemotherapy. Results Thirty five cases were followed up. The time of follow-up ranged from 7 to 116 months,and mean time was(66.0±18.3)months.The 5 year recurrence and bladder-preserving rate were 48.6 ％(17/35)and 68.6 ％(24/35),respectively.The overall and tumor specific survival at 5 years was 77.1％ (27/35)and 82.9 ％ (29/35).The effect of bladder-preserving local resection plus intra-artery chemotherapy was satisfactory. Moreover, intra-artery chemotherapy had no obvious side effects.Conclusion Bladder-preserving local resection combined with intra-artery chemotherapy not only can retain normal bladder function, decrease in the recurrence, but also does not reduce the survival rate. It is an effective treatment for some patients with T1G3 bladder cancer instead of cystectomy over-treatment.
ABSTRACT
Objective To evaluate the direction effect of drug sensitivity test of bladder cancer and the individual choice of chemotherapy. Methods MTT was used to determine chemotherapy and all 34 patients were followed up for 6-43 months. 48 cases were based on the experience of doctors control. Results The sensitive cases were ADM19, THP16, MMC20, OPT30. The sensitive rate was epi-ADM 59.4 %, THP 47.6 %, MMC 41.2 %, OPT 88.2 %. The recurrence rate was 8.82 % in drug sensitivity group, 31.2 % in control group, the result of experiment group was perfect to the control.group. Conclusion The difference of the individual chemotherapy sensitivity is significant. The drug sensitivity test can improve the therapeutic effect of bladder cancer.